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KMID : 0389420090170020163
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Korean Journal of Stress Research
2009 Volume.17 No. 2 p.163 ~ p.168
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SNPs and Haplotypes of Ets variant 6 (ETV6) Gene Is Associated with Overweight/Obese in Korean Population
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Song Jeong-Yoon
Jung Kyung-Hee
Kim Su-Kang
Kang Sung-Wook
Park Hyung-Kyung
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Abstract
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Ets variant 6 (ETV6) gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia. In recent study, it is reported that excess body weight may be a risk factor for leukemia and overweight/obesity have greater risk of leukemia compared to non-overweight individuals. For a possible relation of the genetic polymorphism of ETV6 with overweight/obesity, we genotyped fifty-five single nucleotide polymorphisms (SNPs) of ETV6 using the Affymetrix Genotyping chip array in 206 overweight/obese and 152 normal subjects in the Korean population. Logistic and multiple regression models were employed to analyze the genetic contributions of polymorphisms. Of the fifty five polymorphisms, the four SNPs showed a significant association with overweight/obesity in 3 alternative models (codominant, dominant, and recessive models; p<0.05 after adjusting for age and sex) were rs2723825, rs17818048, rs2710304, and rs7296981. Two haplotypes of ETV6 (block 7: GGG; block 9: CCC) containing significant polymorphisms (rs17818048, rs2710304, and rs7296981) exhibited significant association with the risk of overweight/obesity. Our results suggest that polymorphisms in ETV6 may be associated with overweight/obese in Korean population.
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KEYWORD
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Ets variant 6 (ETV6), Haplotype, Obesity, Single nucleotide polymorphism (SNP)
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